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Article

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis.

Nature cell biology - 1 Jul 2018

Giladi Amir, Paul Franziska, Herzog Yoni, Lubling Yaniv, Weiner Assaf, Yofe Ido, Jaitin Diego, Cabezas-Wallscheid Nina, Dress Regine, Ginhoux Florent, Trumpp Andreas, Tanay Amos, Amit Ido

Abstract excerpt

The dynamics of haematopoietic stem cell differentiation and the hierarchy of oligopotent stem cells in the bone marrow remain controversial. Here we dissect haematopoietic progenitor populations at single cell resolution, deriving an unbiased reference model of transcriptional states in normal and perturbed murine bone marrow. We define the signature of the naive haematopoietic stem cell and find a continuum of...

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PMID: 29915358
DOI: 10.1038/s41556-018-0121-4

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