Article
Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells.
Genome biology - 21 Sept 2015
Tsang Jason C H, Yu Yong, Burke Shannon, Buettner Florian, Wang Cui, Kolodziejczyk Aleksandra A, Teichmann Sarah A, Lu Liming, Liu Pentao
Abstract excerpt
BACKGROUND: Hematopoietic stem cells (HSCs) are a rare cell type with the ability of long-term self-renewal and multipotency to reconstitute all blood lineages. HSCs are typically purified from the bone marrow using cell surface markers. Recent studies have identified significant cellular heterogeneities in the HSC compartment with subsets of HSCs displaying lineage bias. We previously discovered that the...
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