Article

Interplay between <i>TERT</i> promoter mutations and methylation culminates in chromatin accessibility and <i>TERT</i> expression

2019-11-29

Abstract excerpt

The telomerase reverse transcriptase ( TERT ) gene is responsible for telomere maintenance in germline and stem cells, and is re-expressed in 90% of human cancers. Contrary to common concepts, CpG methylation in the TERT promoter ( TERT p), was correlated with TERT mRNA expression. Furthermore, two hotspot mutations in TERT p, dubbed C228T and C250T, have been revealed to assist binding of transcription fact...

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Literature Corpus work: f25bc6fb-2a3d-522a-9e3f-78a80d1e99a4
DOI: 10.1101/859892

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