Article

Pervasive promoter hypermethylation of silenced <i>TERT</i> alleles in human cancers

2020-01-30

Abstract excerpt

<h4>ABSTRACT</h4> In cancers, maintenance of telomeres often occurs through activation of the catalytic subunit of telomerase, encoded by TERT . Yet, most cancers show only modest levels of telomerase gene expression, even in the context of activating hotspot promoter mutations (C228T and C250T). The role of epigenetic mechanisms, including DNA methylation, in regulating telomerase gene expression in cancer cell...

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Literature Corpus work: 55659af4-37ec-5a40-8e9a-740a78ef8578
DOI: 10.1101/2020.01.29.925552

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