Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TERT promoter mutations in cancer development.

Current opinion in genetics & development - 1 Feb 2014

Heidenreich Barbara, Rachakonda P Sivaramakrishna, Hemminki Kari, Kumar Rajiv

Abstract excerpt

Human telomerase reverse transcriptase (TERT) encodes a rate-limiting catalytic subunit of telomerase that maintains genomic integrity. TERT expression is mostly repressed in somatic cells with exception of proliferative cells in self-renewing tissues and cancer. Immortality associated with cancer cells has been attributed to telomerase over-expression. The precise mechanism behind the TERT activation in cancers...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to TERT gene
Share to Mutation
Share to Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair Mechanisms

Share to Nucleic Acid Conformation

Share to Promoter Regions, Genetic

Share to Telomerase

Share to Telomeres, Telomerase, and Senescence

Source

Identifiers

PMID: 24657534
DOI: 10.1016/j.gde.2013.11.005

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TERT promoter mutations in cancer development.PMID 24657534Read ↗

TERT Promoter Mutations and Telomerase in MelanomaSemantic proximity Read ↗

Highly recurrent TERT promoter mutations in human melanoma.Semantic proximity Read ↗

TERT promoter mutations in telomere biology.Semantic proximity Read ↗

Reactivation of telomerase in cancer.Semantic proximity Read ↗

Understanding TERT Promoter Mutations: A Common Path to Immortality.Semantic proximity Read ↗

Reactivation of telomerase reverse transcriptase expression in cancer: the role of TERT promoter mutationsSemantic proximity Read ↗

TERT—Regulation and Roles in Cancer FormationSemantic proximity Read ↗

TERT promoter mutations in thyroid cancer.Semantic proximity Read ↗

TERT promoter mutations are frequent in cutaneous basal cell carcinoma and squamous cell carcinoma.Semantic proximity Read ↗

TERT promoter mutations in familial and sporadic melanoma.Semantic proximity Read ↗

TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma.Semantic proximity Read ↗

Mechanistic basis of atypical TERT promoter mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.