Article

Recurrent promoter mutations in melanoma are defined by an extended context-specific mutational signature

2016-08-12

Abstract excerpt

<h4>Summary</h4> Sequencing of whole tumor genomes holds the promise of revealing functional somatic regulatory mutations, such as those described in the TERT promoter. Recurrent promoter mutations have been identified in many additional genes and appear to be particularly common in melanoma, but convincing functional data such as influence on gene expression has been more elusive. Here, we show that frequently...

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Literature Corpus work: a5edbf01-588f-51b0-bdef-5c65d8278fb6
DOI: 10.1101/069351

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