Article
Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes.
Cell reports - 26 Dec 2017
Stern Josh Lewis, Paucek Richard D, Huang Franklin W, Ghandi Mahmoud, Nwumeh Ronald, Costello James C, Cech Thomas R
Abstract excerpt
A mutation in the promoter of the Telomerase Reverse Transcriptase (TERT) gene is the most frequent noncoding mutation in cancer. The mutation drives unusual monoallelic expression of TERT, allowing immortalization. Here, we find that DNA methylation of the TERT CpG island (CGI) is also allele-specific in multiple cancers. The expressed allele is hypomethylated, which is opposite to cancers without TERT promoter...
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