Article

SARS-CoV-2 D614G Variant Exhibits Enhanced Replication <i>ex vivo</i> and Earlier Transmission <i>in vivo</i>

2020-09-29

Abstract excerpt

The D614G substitution in the S protein is most prevalent SARS-CoV-2 strain circulating globally, but its effects in viral pathogenesis and transmission remain unclear. We engineered SARS-CoV-2 variants harboring the D614G substitution with or without nanoluciferase. The D614G variant replicates more efficiency in primary human proximal airway epithelial cells and is more fit than wildtype (WT) virus in competitio...

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Literature Corpus work: f23b3a75-25bc-56d1-9b68-a2b65c766c33
DOI: 10.1101/2020.09.28.317685

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