Article

S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness

2023-03-31

Abstract excerpt

<h4>Abstract/Summary</h4> SARS-CoV-2 variants bearing complex combinations of mutations that confer increased transmissibility, COVID-19 severity, and immune escape, were first detected after S:D614G had gone to fixation, and likely originated during persistent infection of immunocompromised hosts. To test the hypothesis that S:D614G facilitated emergence of such variants, S:D614G was reverted to the ancestral se...

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Literature Corpus work: 99258418-d04c-519b-9aef-9da237b86bb6
DOI: 10.1101/2023.03.30.535005

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