Article

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

2020-07-04

Abstract excerpt

<h4>SUMMARY</h4> The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide in a matter of months. Here we show that D614G was more infectious than the ancestral form on human lung cells, colon cells, and cells rendered permissive by ectopic expression of various mammalian ACE2 orthologs. Nonetheless, D614G affinity for ACE2 was reduced due to a faster dissociation rate. Assessment of...

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Literature Corpus work: 7d274214-fb29-5884-85ec-7bbe33c332d7
DOI: 10.1101/2020.07.04.187757

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