Article

S:D614G and S:H655Y are Gateway Mutations that Act Epistatically to Promote SARS-CoV-2 Variant Fitness

2023-05-17

Abstract excerpt

SARS-CoV-2 variants bearing complex combinations of mutations were first detected after S:D614G had gone to fixation. Consistent with the hypothesis that variant emergence was contingent upon S:D614G, the infectivity of SARS-CoV-2 variants was shown here to be dependent upon S:D614G. SARS-CoV-2 lineages that propagated in the absence of S:D614G were found to be dependent upon either S:Q613H or S:H655Y. S:Q613H, S:...

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Literature Corpus work: 801f1500-ca1a-5fbf-8b36-42acafda2c0e
DOI: 10.2139/ssrn.4446761

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