Article

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

2020-09-10

Abstract excerpt

<title>Abstract</title> <p>A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19 pandemic. However, the mutational impact on viral spread and vaccine efficacy remains to be defined. Here we engineer the D614G mutation in the SARS-CoV-2 USA-WA1/2020 strain and characterize its effect on viral replication, pathogenesis, and antibody neutralization. The D614G mutation significantly enhance...

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Literature Corpus work: a5d77017-63b5-58b6-80a8-fe6457a935e0
DOI: 10.21203/rs.3.rs-70482/v1

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