Article

T492I mutation alters SARS-CoV-2 properties via modulating viral non-structural proteins

2023-01-17

Abstract excerpt

<h4>ABSTRACT</h4> The historically dominant SARS-CoV-2 Delta variants and the currently dominant Omicron variants carry a T492I substitution within the non-structural protein 4 (NSP4). Based on a combination of in silico analyses, we predicted that the T492I mutation increases the transmissibility and adaptability of the virus. We confirmed this hypothesis by performing competition experiments in hamsters and in...

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Literature Corpus work: 4c4a151a-d790-5f86-86d3-9709c297d81d
DOI: 10.1101/2023.01.15.524090

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