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Article

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

12 Nov 2020

Abstract excerpt

The spike aspartic acid-614 to glycine (D614G) substitution is prevalent in global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral pathogenesis and transmissibility remain unclear. We engineered a SARS-CoV-2 variant containing this substitution. The variant exhibits more efficient infection, replication, and competitive fitness in primary human airway epithelial...

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PMID: 33184236
DOI: 10.1126/science.abe8499

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