Article

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

2020-09-02

Abstract excerpt

A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19 pandemic. However, the mutational impact on viral spread and vaccine efficacy remains to be defined. Here we engineer the D614G mutation in the SARS-CoV-2 USA-WA1/2020 strain and characterize its effect on viral replication, pathogenesis, and antibody neutralization. The D614G mutation significantly enhances SARS-CoV-2 replication on...

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Literature Corpus work: 6a785dec-4eff-53c7-8348-ee2e560416b7
DOI: 10.1101/2020.09.01.278689

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