SARS-CoV-2 spike D614G change enhances replication and transmission.

doi:10.1038/s41586-021-03361-1

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Article

SARS-CoV-2 spike D614G change enhances replication and transmission.

Nature - 1 Apr 2021

Zhou Bin, Thao Tran Thi Nhu, Hoffmann Donata, Taddeo Adriano, Ebert Nadine, Labroussaa Fabien, Pohlmann Anne, King Jacqueline, Steiner Silvio, Kelly Jenna N, Portmann Jasmine, Halwe Nico Joel, Ulrich Lorenz, Trüeb Bettina Salome, Fan Xiaoyu, Hoffmann Bernd, Wang Li, Thomann Lisa, Lin Xudong, Stalder Hanspeter, Pozzi Berta, de Brot Simone, Jiang Nannan, Cui Dan, Hossain Jaber, Wilson Malania M, Keller Matthew W, Stark Thomas J, Barnes John R, Dijkman Ronald, Jores Joerg, Benarafa Charaf, Wentworth David E, Thiel Volker, Beer Martin

Abstract excerpt

During the evolution of SARS-CoV-2 in humans, a D614G substitution in the spike glycoprotein (S) has emerged; virus containing this substitution has become the predominant circulating variant in the COVID-19 pandemic1. However, whether the increasing prevalence of this variant reflects a fitness advantage that improves replication and/or transmission in humans or is merely due to founder effects remains unknown....

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PMID: 33636719
DOI: 10.1038/s41586-021-03361-1

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