Article

<i>KEAP1</i> mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancer

2025-08-13

Abstract excerpt

<h4>ABSTRACT</h4> The KEAP1/NRF2 pathway, a major regulator of the cellular oxidative stress response, is frequently activated in human cancers. Often mediated by loss-of-function mutations in KEAP1 , this activation causes increased NRF2 transcriptional activity and constitutive activation of the antioxidant response. While KEAP1 mutations have been well documented in various cancers, their presence and role i...

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Literature Corpus work: f1e3ae65-65ce-5392-93d8-5db21ae88e5d
DOI: 10.1101/2025.08.13.670155

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