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Article

Somatic mutations of the KEAP1 gene in common solid cancers.

Histopathology - 1 May 2012

Yoo Nam Jin, Kim Hyung Ran, Kim Yoo Ri, An Chang Hyeok, Lee Sug Hyung

Abstract excerpt

AIMS: KEAP1 inhibits nuclear factor erythroid 2-related factor 2 (NRF2)-induced cytoprotection, and is considered to be a candidate tumour suppressor. Somatic mutation of NRF2 has been analysed in a wide variety of human cancers, whereas somatic mutation of KEAP1 has been reported only in lung and gall bladder cancers. The aim of our study was to investigate whether KEAP1 mutations are widespread in human...

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Source

Identifiers

PMID: 22348534
DOI: 10.1111/j.1365-2559.2012.04178.x

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutations of the KEAP1 gene in common solid cancers.PMID 22348534Read ↗

Specific cancer types and prognosis in patients with variations in the KEAP1-NRF2 system: A retrospective cohort study.Semantic proximity Read ↗

The tumor suppressive role of KEAP1: Underlying mechanisms and therapeutic implications.Semantic proximity Read ↗

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.Semantic proximity Read ↗

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin.Semantic proximity Read ↗

<i>KEAP1</i> mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancerSemantic proximity Read ↗

A catalogue of somatic NRF2 gain-of-function mutations in cancerSemantic proximity Read ↗

Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer.Semantic proximity Read ↗

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells.Semantic proximity Read ↗

Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activationSemantic proximity Read ↗

Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer.Semantic proximity Read ↗

Oxidative Stress-Related KEAP1 and NRF2 Genes Contributed to the Risk of Epithelial Ovarian Cancer.Semantic proximity Read ↗

Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma.Semantic proximity Read ↗

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