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Article

The tumor suppressive role of KEAP1: Underlying mechanisms and therapeutic implications.

Biochimica et biophysica acta. Molecular basis of disease - 1 Aug 2026

Zhang Ziyu, Jin Xiangting, Chen Junhong, Liu Kai, Dai Xiangpeng

Abstract excerpt

Kelch-like ECH-associated protein 1 (KEAP1) serves as an adaptor protein for the Cullin3-RING E3 ubiquitin ligase complex, orchestrating the ubiquitination and subsequent degradation of its substrates including the transcription factor NF-E2-related factor 2 (NRF2) to regulate cell functions. Emerging evidence demonstrates that genetic alterations (mutations or functional inactivation) of KEAP1 occur frequently...

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Source

Identifiers

PMID: 41967615
DOI: 10.1016/j.bbadis.2026.168260

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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The tumor suppressive role of KEAP1: Underlying mechanisms and therapeutic implications.PMID 41967615Read ↗

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