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Article

Oncogenic mutations in KEAP1 disturbing inhibitory Nrf2-Keap1 interaction: Activation of antioxidative pathway in papillary thyroid carcinoma.

Head & neck - 1 Jun 2018

Danilovic Debora Lucia Seguro, de Mello Evandro Sobroza, Frazzato Eliana Salgado Turri, Wakamatsu Alda, de Lima Jorge Alexander Augusto, Hoff Ana Oliveira, Marui Suemi

Abstract excerpt

BACKGROUND: Nuclear factor erythroid 2-like 2 (NFE2L2) encodes Nrf2, transcription factor of antioxidative genes. In the presence of reactive oxygen species, Keap1 (Kelch-ECH-associating protein-1) inhibitor complex undergoes conformational changes disrupting Keap1-Nrf2 binding and Nrf2 translocates into nucleus. We evaluated the presence of mutations in NFE2L2 and KEAP1 in papillary thyroid carcinomas (PTCs) and...

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Source

Identifiers

PMID: 29469959
DOI: 10.1002/hed.25105

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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