Article
Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma.
Cell death & disease - 9 Aug 2022
Islam Syed S, Qassem Khawlah, Islam Shafiqul, Parag Rashed R, Rahman Mohammed Z, Farhat Walid A, Yeger Herman, Aboussekhra Abdelilah, Karakas Bedri, Noman Abu Shadat M
Abstract excerpt
Keap1 mutations regulate Nrf2 activity and lead to chemoresistance in cancers. Yet the underlying molecular mechanisms of chemoresistance are poorly explored. By focusing and genotyping head and neck squamous cell carcinoma (HNSCC) that had available pathologic and clinical data, we provide evidence that Keap1 displays frequent alterations (17%) in HNSCC. Functional loss of Keap1 results in significant activation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.