Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer.

Molecular cancer - 20 Oct 2013

Martinez Victor D, Vucic Emily A, Pikor Larissa A, Thu Kelsie L, Hubaux Roland, Lam Wan L

Abstract excerpt

BACKGROUND: Reactive oxygen species contribute to normal thyroid function. The NRF2 oxidative response pathway is frequently and constitutively activated in multiple tumor types, including papillary thyroid carcinoma (PTC). Genetic mechanisms underlying NRF2 pathway activation in PTC are not fully understood. Thus, we aimed to determine whether inactivating patterns of DNA-level alterations affect genes encoding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Carcinoma, Papillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cullin Proteins

Share to Kelch-Like ECH-Associated Protein 1

Share to NF-E2-Related Factor 2

Share to Reactive Oxygen Species

Share to Thyroid Cancer, Papillary

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 24138990
DOI: 10.1186/1476-4598-12-124
PMCID: PMC4016213

Genes

CUL3
KEAP1
RBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer.PMID 24138990Read ↗

Oncogenic mutations in KEAP1 disturbing inhibitory Nrf2-Keap1 interaction: Activation of antioxidative pathway in papillary thyroid carcinoma.Semantic proximity Read ↗

<i>KEAP1</i> mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancerSemantic proximity Read ↗

Integrated genomic characterization of papillary thyroid carcinoma.Semantic proximity Read ↗

Promoter mutation-independent TERT expression is related to the immune-enriched milieu in papillary thyroid cancer.Semantic proximity Read ↗

Decoding the Mutational Hierarchy of Thyroid Cancer and Associated Signaling Pathways.Semantic proximity Read ↗

Papillary Thyroid Cancer Remodels the Genomic Fabrics of DNA Replication, Repair and TranscriptionSemantic proximity Read ↗

Gene expression in papillary thyroid carcinoma reveals highly consistent profilesSemantic proximity Read ↗

Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid carcinomas.Semantic proximity Read ↗

LncRNA HOTAIR impairs the prognosis of papillary thyroid cancer via regulating cellular malignancy and epigenetically suppressing DLX1Semantic proximity Read ↗

Determination of the mutational landscape in Taiwanese patients with papillary thyroid cancer by whole-exome sequencing.Semantic proximity Read ↗

Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer.Semantic proximity Read ↗

Changes in the transcriptome of thyroid cancer cell lines after radiotherapy and analysis of the potential mechanisms regulating radiotherapy sensitivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.