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Article

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.

Cancer research - 1 Feb 2014

Hast Bridgid E, Cloer Erica W, Goldfarb Dennis, Li Heng, Siesser Priscila F, Yan Feng, Walter Vonn, Zheng Ning, Hayes D Neil, Major Michael B

Abstract excerpt

NRF2 is a transcription factor that mediates stress responses. Oncogenic mutations in NRF2 localize to one of its two binding interfaces with KEAP1, an E3 ubiquitin ligase that promotes proteasome-dependent degradation of NRF2. Somatic mutations in KEAP1 occur commonly in human cancer, where KEAP1 may function as a tumor suppressor. These mutations distribute throughout the KEAP1 protein but little is known about...

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Topics

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Share to Intracellular Signaling Peptides and Proteins
Share to Kelch-Like ECH-Associated Protein 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NF-E2-Related Factor 2

Share to Protein Conformation

Share to Protein Multimerization

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Source

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Identifiers

PMID: 24322982
DOI: 10.1158/0008-5472.CAN-13-1655
PMCID: PMC3932503

Genes

KEAP1
CUL3

Variants

Provenance

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Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.PMID 24322982Read ↗

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