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Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation

23 Jun 2020

Abstract excerpt

BACKGROUND AND PURPOSE: Targeted therapy and immunotherapy have led to dramatic change in the treatment of lung cancer, however, the overall 5-year survival rate of lung cancer patients is still suboptimal. It is important to exploit new potential of molecularly targeted therapies. High-frequency somatic mutations in KEAP1/NRF2 (27.9%) have been identified in lung squamous cell carcinoma. In this research, we...

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PMID: 32576270
DOI: 10.1186/s12964-020-00568-z

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