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Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma

2023-01-17

Abstract excerpt

<title>Abstract</title> <p><italic>Keap1</italic> mutations regulate <italic>Nrf2</italic> activity and lead to chemoresistance in cancers. Yet the underlying molecular mechanisms of chemoresistance are poorly explored. By focusing and genotyping head and neck squamous cell carcinoma (HNSCC) that had available pathologic and clinical data, we provide evidence that <italic>Keap1</italic> displays frequent alterati...

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Literature Corpus work
e20caaeb-b4a5-57ef-b611-16d02d488fa8
DOI
10.21203/rs.3.rs-1518797/v1
Open publication

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Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinomaDOI 10.21203/rs.3.rs-1518797/v1
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