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Article

Specific cancer types and prognosis in patients with variations in the KEAP1-NRF2 system: A retrospective cohort study.

Cancer science - 1 Dec 2024

Iwasaki Tomoyuki, Shirota Hidekazu, Sasaki Keiju, Ouchi Kota, Nakayama Yuki, Oshikiri Hiroyuki, Otsuki Akihito, Suzuki Takafumi, Yamamoto Masayuki, Ishioka Chikashi

Abstract excerpt

The KEAP1-NRF2 system induces the expression of antioxidant genes in response to various types of oxidative stress. Some cancer cells activate this system, which increases their malignancy through genetic mutations. We performed a retrospective cohort study using the C-CAT database, which contains the gene-panel sequence data from 60,056 cases of diagnosed solid tumors. We analyzed somatic mutations in NRF2 and...

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Source

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Identifiers

PMID: 39327066
DOI: 10.1111/cas.16355
PMCID: PMC11611756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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