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Article

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.

PLoS medicine - 1 Oct 2006

Singh Anju, Misra Vikas, Thimmulappa Rajesh K, Lee Hannah, Ames Stephen, Hoque Mohammad O, Herman James G, Baylin Stephen B, Sidransky David, Gabrielson Edward, Brock Malcolm V, Biswal Shyam

Abstract excerpt

BACKGROUND: Nuclear factor erythroid-2 related factor 2 (NRF2) is a redox-sensitive transcription factor that positively regulates the expression of genes encoding antioxidants, xenobiotic detoxification enzymes, and drug efflux pumps, and confers cytoprotection against oxidative stress and xenobiotics in normal cells. Kelch-like ECH-associated protein 1 (KEAP1) negatively regulates NRF2 activity by targeting it...

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Source

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Identifiers

PMID: 17020408
DOI: 10.1371/journal.pmed.0030420
PMCID: PMC1584412

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.PMID 17020408Read ↗

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