Article

Single cell long read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML

2025-08-22

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are caused by acquired mutations in hematopoietic stem and progenitor cells (HSPCs). The acquisition of additional mutations like TP53 and the overall mutational burden influence a patient’s risk of disease progression toward lethal post-MPN acute myeloid leukemia (AML). Recent technological advancements in linking single-cell gene expression with genotype have improved our un...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1df01d2-a6d9-513e-9e61-0246ea966a9a
DOI: 10.1101/2025.08.18.670417

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell long read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AMLDOI 10.1101/2025.08.18.670417Read

Single-cell long-read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML.Semantic proximity Read

A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencingSemantic proximity Read

Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing.Semantic proximity Read

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AMLSemantic proximity Read

Scalable genotyping in fixed transcriptomes resolves clonal heterogeneity via single-cell sequencingSemantic proximity Read

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.Semantic proximity Read

Integrative genotyping of cancer and immune phenotypes by long-read sequencing.Semantic proximity Read

Mutation detection in thousands of acute myeloid leukemia cells using single cell RNA-sequencingSemantic proximity Read

Multiomic Single Cell Sequencing Identifies Stemlike Nature of Mixed Phenotype Acute Leukemia and Provides Novel Risk StratificationSemantic proximity Read

Whole Exome Sequencing and Single-Cell DNA Sequencing for Assessment of Clonal Heterogeneity and Evolution in Acute Myeloid LeukemiaSemantic proximity Read

Rapid Molecular Profiling of Myeloproliferative Neoplasms Using Targeted Exon Resequencing of 86 Genes Involved in JAK-STAT Signaling and Epigenetic Regulation.Semantic proximity Read

Clonal Metamorphosis: Deconstructing MPN Evolution with Single-Cell and Spatial Multi-Omics.Semantic proximity Read