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Article

Integrative genotyping of cancer and immune phenotypes by long-read sequencing.

Nature communications - 2 Jan 2024

Penter Livius, Borji Mehdi, Nagler Adi, Lyu Haoxiang, Lu Wesley S, Cieri Nicoletta, Maurer Katie, Oliveira Giacomo, Al'Khafaji Aziz M, Garimella Kiran V, Li Shuqiang, Neuberg Donna S, Ritz Jerome, Soiffer Robert J, Garcia Jacqueline S, Livak Kenneth J, Wu Catherine J

Abstract excerpt

Single-cell transcriptomics has become the definitive method for classifying cell types and states, and can be augmented with genotype information to improve cell lineage identification. Due to constraints of short-read sequencing, current methods to detect natural genetic barcodes often require cumbersome primer panels and early commitment to targets. Here we devise a flexible long-read sequencing workflow and...

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Identifiers

PMID: 38167262
DOI: 10.1038/s41467-023-44137-7
PMCID: PMC10762175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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