Article

Post-hoc long-read sequencing links leukemic mutation status to single-cell transcriptomes

2026-05-11

Abstract excerpt

Single-cell RNA-sequencing-based characterization of cells that belong to the neoplastic clone is a major challenge in hematologic neoplasms, where malignant and normal cells coexist. Confident molecular profiling requires simultaneous analysis of gene expression and genetic mutations in individual cells, an ability that is not supported by the standard 10X Genomics workflow. Here, we systematically evaluated the...

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Literature Corpus work: 0400880f-87f3-5d0a-b83b-6f7bb2dc3895
DOI: 10.64898/2026.05.06.723232

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