Article

Mutation detection in thousands of acute myeloid leukemia cells using single cell RNA-sequencing

2018-10-17

Abstract excerpt

Virtually all tumors are genetically heterogeneous, containing subclonal populations of cells that are defined by distinct mutations 1 . Subclones can have unique phenotypes that influence disease progression 2 , but these phenotypes are difficult to characterize: subclones usually cannot be physically purified, and bulk gene expression measurements obscure interclonal differences. Single-cell RNA-sequencing has...

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Literature Corpus work: db9f1424-56db-5ed1-a6f0-50adbe46a842
DOI: 10.1101/434746

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