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Article

Single-cell long-read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML.

Blood advances - 28 Jul 2026

Grabek Julian, Straube Jasmin, Cooper Leanne, Haldar Rohit, Zhang Ranran, Dulige Inken, Barker Matthew, Gatehouse Will, Christensen Helen, Amor Gerlinda, Ling Victoria Y, McNamara Caroline, Ross David M, Perkins Andrew, Bywater Megan J, Lane Steven W

Abstract excerpt

ABSTRACT: Myeloproliferative neoplasms (MPNs) are caused by acquired mutations in hematopoietic stem and progenitor cells (HSPCs). The acquisition of additional mutations, such as TP53, and the overall mutational burden influence a patient's risk of disease progression to lethal post-MPN acute myeloid leukemias (AML). Recent technological advancements in linking single-cell gene expression with genotype have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 42101375
DOI: 10.1182/bloodadvances.2025018902
PMCID: PMC13382927

Genes

CP
JAK2
TP53
IDH1
SRSF2
U2AF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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