Article
Rapid Molecular Profiling of Myeloproliferative Neoplasms Using Targeted Exon Resequencing of 86 Genes Involved in JAK-STAT Signaling and Epigenetic Regulation.
The Journal of molecular diagnostics : JMD - 1 Sept 2016
Magor Graham W, Tallack Michael R, Klose Nathan M, Taylor Debra, Korbie Darren, Mollee Peter, Trau Matt, Perkins Andrew C
Abstract excerpt
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of blood disorders characterized by excess production of mature blood cells and an increased risk of late transformation to acute myeloid leukemia or primary myelofibrosis. Approximately 15% of MPN cases do not carry mutations in JAK2, CALR, or MPL and are thus often referred to as triple-negative cases. These are caused by a diverse set of rare...
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