Article

A unified cross-attention model for predicting antigen binding specificity to both HLA and TCR molecules

2024-05-10

Abstract excerpt

<title>Abstract</title> <p>The immune checkpoint inhibitors have demonstrated promising clinical efficacy across various tumor types, yet the percentage of patients who benefit from them remains low. The bindings between tumor antigens and HLA-I/TCR molecules determine the antigen presentation and T-cell activation, thereby playing important role in the immunotherapy response. Some computational methods have been...

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Literature Corpus work: f1c13659-ebd4-5585-9a2b-d05516e1b688
DOI: 10.21203/rs.3.rs-4321674/v1

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