Article

EPIC-TRACE: predicting TCR binding to unseen epitopes using attention and contextualized embeddings

2023-06-28

Abstract excerpt

T cells play an essential role in adaptive immune system to fight pathogens and cancer but may also give rise to autoimmune diseases. The recognition of a peptide-MHC (pMHC) complex by a T cell receptor (TCR) is required to elicit an immune response. Many machine learning models have been developed to predict the binding, but generalizing predictions to pMHCs outside the training data remains challenging. We have...

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Literature Corpus work: ebc92c34-9337-5137-8f23-195891b35ef2
DOI: 10.1101/2023.06.26.546489

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