Article

Transformer-Genetic Algorithm Co-Optimization for Neoantigen Prediction in Cancer Immunotherapy

2025-12-02

Abstract excerpt

<title>Abstract</title> <p>Personalized neoantigen vaccine development requires accurate predictions of binding affinity, immunogenicity, and peptide stability across diverse HLA profiles. This paper presents a novel multi-task learning transformer architecture augmented with evolutionary optimization for comprehensive neoantigen prioritization. The proposed framework integrates enhanced positional encoding and b...

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Literature Corpus work: 19556b23-0dd2-5d17-bb3d-b6030b0a101f
DOI: 10.21203/rs.3.rs-8222565/v1

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