Article

A unified deep framework for peptide–major histocompatibility complex–T cell receptor binding prediction

2025-02-26

Abstract excerpt

Antigen peptides that are presented by a major histocompatibility complex (MHC) and recognized by a T cell receptor (TCR) have an essential role in immunotherapy. Although substantial progress has been made in predicting MHC presentation, accurately predicting the binding interactions between antigen peptides, MHCs and TCRs remains a major computational challenge. In this paper, we propose a unified deep framework...

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Identifiers and source

Literature Corpus work: 8306201c-ae81-547a-a0cd-d465f773e5da
DOI: 10.1038/s42256-025-01002-0

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