Article

DeepPROTECTNeo: A Deep learning-based Personalized and RV-guided Optimization tool leveraging TCR Epitope interaction using Context-aware Transformers

2025-01-05

Abstract excerpt

The development of personalized cancer vaccines relies heavily on accurately identifying neoepitopes capable of eliciting strong immune responses. T cell receptor (TCR)-epitope interactions are fundamental to cancer immunotherapy. Despite significant advances, computational approaches primarily focus on epitope-major histocompatibility complex (MHC) binding, often overlooking the critical contribution of T-cell re...

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Literature Corpus work: 821057eb-87b9-54cb-a8ad-31c42a2d859d
DOI: 10.1101/2025.01.04.631301

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