Article

Epitope-anchored contrastive transfer learning for paired CD8 <sup>+</sup> T cell receptor-antigen recognition

2024-04-07

Abstract excerpt

Understanding the mechanisms of T-cell antigen recognition that underpin adaptive immune responses is critical for the development of vaccines, immunotherapies, and treatments against autoimmune diseases. Despite extensive research efforts, the accurate identification of T cell receptor (TCR)-antigen binding pairs remains a significant challenge due to the vast diversity and cross-reactivity of TCRs. Here, we prop...

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Literature Corpus work: 64b8cffa-a500-5850-abce-111c2b45f4fc
DOI: 10.1101/2024.04.05.588255

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