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An Alzheimer’s disease pathway uncovered by functional omics: the risk gene <i>CELF1</i> regulates <i>KLC1</i> splice variant E expression, which drives Aβ pathology

2022-03-02

Abstract excerpt

In an era when numerous disease-associated genes have been identified, determining the molecular mechanisms of complex diseases is still difficult. The CELF1 region was identified by genome-wide association studies as an Alzheimer’s disease (AD) risk locus. Using transcriptomics and cross-linking and immunoprecipitation sequencing (CLIP-seq), we found that CELF1, an RNA-binding protein, binds to KLC1 RNA and regul...

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Literature Corpus work
f1b6acea-d0be-55cc-b1c2-a3ccba614c30
DOI
10.1101/2022.02.28.22271320
Open publication

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An Alzheimer’s disease pathway uncovered by functional omics: the risk gene <i>CELF1</i> regulates <i>KLC1</i> splice variant E expression, which drives Aβ pathologyDOI 10.1101/2022.02.28.22271320
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