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Article

Cross-species comparative hippocampal transcriptomics in Alzheimer’s disease

7 Dec 2023

Abstract excerpt

Alzheimer's disease (AD) is a multifactorial pathology, with most cases having a sporadic origin. Recently, knock-in (KI) mouse models, such as the novel humanized amyloid-β (hAβ)-KI, have been developed to better resemble sporadic human AD. METHODS: Here, we compared hippocampal publicly available transcriptomic profiles of transgenic (5xFAD and APP/PS1) and KI (hAβ-KI) mouse models with early- (EOAD) and late-...

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PMID: 38292167
DOI: 10.1016/j.isci.2023.108671

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