Back to search

Article

Pleiotropic effects of PLEC and C1Q on Alzheimer’s disease and cardiovascular traits

2024-01-31

Abstract excerpt

<title>Abstract</title> <p>Several cardiovascular (CV) traits and diseases co-occur with Alzheimer’s disease (AD). We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 19 genetic loci associated with both AD and CV diseases. We prioritised rs11786896, which colocalised with AD, atrial fibrillation (AF) and expression...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7901b320-9bf8-556b-ba2e-c904b100c0c7
DOI
10.21203/rs.3.rs-3851905/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Pleiotropic effects of PLEC and C1Q on Alzheimer’s disease and cardiovascular traitsDOI 10.21203/rs.3.rs-3851905/v1
Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.Semantic proximity
Exome-Wide Association Study Identified Clusters of Pleiotropic Genetic Associations with Alzheimer's Disease and Thirteen Cardiovascular Traits.Semantic proximity
Investigating genetic overlap between Alzheimer's disease, lipids, and coronary artery disease: a large-scale genome-wide cross trait analysisSemantic proximity
Large-scale genetic study identifies shared genetic regions between cerebrovascular and neurodegenerative diseases.Semantic proximity
Investigating Genetic Overlap between Alzheimer's Disease, Lipids, and Coronary Artery Disease: A Large-Scale Genome-Wide Cross Trait Analysis.Semantic proximity
Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traitsSemantic proximity
Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry.Semantic proximity
Comprehensive analysis of genetic risk loci uncovers novel candidate genes and pathways in the comorbidity between depression and Alzheimer’s diseaseSemantic proximity
A multi-trait genome-wide association study of coronary artery disease and subclinical atherosclerosis traitsSemantic proximity
Shared genetic aetiology of Alzheimer’s disease and age-related macular degeneration by APOC1 and APOE genesSemantic proximity
Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits.Semantic proximity
Local genetic correlation analysis of Alzheimer’s disease and stroke implicates <i>PHLPP1</i> as a shared locus in individuals of African ancestrySemantic proximity
Select a neighboring publication to make it the new centre.