Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.

doi:10.1038/s41467-024-53452-6

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Article

Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.

Nature communications - 13 Nov 2024

Koskeridis Fotios, Fancy Nurun, Tan Pei Fang, Meena Devendra, Evangelou Evangelos, Elliott Paul, Wang Dennis, Matthews Paul M, Dehghan Abbas, Tzoulaki Ioanna

Abstract excerpt

Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic loci associated with both Alzheimer's and cardiovascular diseases. We prioritised rs11786896, which colocalised with Alzheimer's disease, atrial fibrillation and expression of...

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PMID: 39537608
DOI: 10.1038/s41467-024-53452-6
PMCID: PMC11561119

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