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Article

Coexistence of Multiple Functional Variants and Genes Underlies Genetic Risk Locus 11p11.2 of Alzheimer's Disease.

Biological psychiatry - 1 Nov 2023

Xu Min, Liu Qianjin, Bi Rui, Li Yu, Li Hongli, Kang Wei-Bo, Yan Zhongjiang, Zheng Quanzhen, Sun Chunli, Ye Maosen, Xiang Bo-Lin, Luo Xiong-Jian, Li Ming, Zhang Deng-Feng, Yao Yong-Gang

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified dozens of genetic risk loci for Alzheimer's disease (AD), yet the underlying causal variants and biological mechanisms remain elusive, especially for loci with complex linkage disequilibrium and regulation. METHODS: To fully untangle the causal signal at a single locus, we performed a functional genomic study of 11p11.2 (the CELF1/SPI1 locus)....

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Source

Identifiers

PMID: 37290560
DOI: 10.1016/j.biopsych.2023.05.020

Genes

SPI1
ACP2
C1QTNF4
CELF1
MADD
MTCH2
NDUFS3
PSMC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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