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A <i>multiple-causal-gene-cluster</i> model underlying GWAS signals of Alzheimer’s disease

2021-05-17

Abstract excerpt

Genome-wide association studies (GWASs) have identified dozens of genetic susceptibility loci for Alzheimer’s disease (AD). Nevertheless, the underlying causal variants and biological mechanisms remain elusive. Here, we systematically integrated AD GWAS with comprehensive multi-omics data, and distilled 304 potentially functional variants and 166 causal genes from 49 loci. Intriguingly, we found that most of AD GW...

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Literature Corpus work
186b0f86-6123-57ea-a6bf-93d08a31492a
DOI
10.1101/2021.05.14.444131
Open publication

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A <i>multiple-causal-gene-cluster</i> model underlying GWAS signals of Alzheimer’s diseaseDOI 10.1101/2021.05.14.444131
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