Article

Cross-species comparative hippocampal transcriptomics in Alzheimer’s disease

2021-06-10

Abstract excerpt

<h4>Summary</h4> Alzheimer’s disease (AD) is a multifactorial pathology, with most cases having a sporadic origin. Recently, knock-in (KI) models have been developed with the promise of resembling better sporadic human AD, such as the novel hAβ-KI mouse. Here, we compared hippocampal publicly available transcriptomic profiles of transgenic (5xFAD and APP/PS1) and KI (hAβ-KI) mouse models with early- (EOAD) and la...

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Literature Corpus work: 03941d74-2b48-57e5-8592-e8c2c3be969b
DOI: 10.1101/2021.06.09.447404

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