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The Glial Aging & Senescence Hypothesis of Late-onset Alzheimer’s

2022-03-07

Abstract excerpt

Alzheimer’s disease (AD) predominantly occurs as a late-onset form (LOAD), involving neurodegeneration and cognitive decline with progressive memory loss. Over time, risk factors and aging promote accumulation of well-known AD pathologies in oxidative stress, amyloid-beta and tau protein pathology, as well as inflammation. Homeostatic glial functions regulate and suppress these AD pathologies; however, other...

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Literature Corpus work
edceab48-4eb1-599c-afc1-b8982be628f8
DOI
10.20944/preprints202109.0437.v2
Open publication

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