Article
Microglia Phenotypes in Aging and Neurodegenerative Diseases.
Cells - 30 Jun 2022
Wendimu Menbere Y, Hooks Shelley B
Abstract excerpt
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a fundamental role in mediating the onset and progression of disease. Microglia, which function as first-line immune guardians of the central nervous system (CNS), are the central drivers of neuroinflammation. Numerous human postmortem studies and in vivo imaging analyses have shown chronically activated microglia in patients with...
Topics
- Animals
- Central Nervous System
- Microglia
- Neurodegenerative Diseases
- Parkinson Disease
- Phenotype