Article

Efficient RNA-mediated reprogramming of human somatic cells to naïve pluripotency facilitated by tankyrase inhibition

2019-05-14

Abstract excerpt

<h4>ABSTRACT</h4> In contrast to conventional human pluripotent stem cells (hPSC) that are related to post-implantation embryo stages, naïve hPSC exhibit features of pre-implantation epiblast. Naïve hPSC are established by resetting conventional hPSC, or are derived from dissociated embryo inner cell masses. Here we investigate conditions for transgene-free reprogramming of human somatic cells to naïve pluripoten...

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Literature Corpus work: 25407179-952c-5a58-8731-6fcc8577503f
DOI: 10.1101/636670

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