Article

Investigating the Role and Regulation of GPNMB in Progranulin-deficient Macrophages

2024-03-14

Abstract excerpt

<h4>ABSTRACT</h4> Progranulin is a holoprotein that is critical for successful aging, and insufficient levels of progranulin are associated with increased risk for developing age-related neurodegenerative diseases like AD, PD, and FTD. Symptoms can vary widely, but a uniting feature among these different neurodegenerative diseases is prodromal peripheral immune cell phenotypes. However, there remains considerable...

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Literature Corpus work: f173130a-1e07-5a23-831f-28e8d20cca8e
DOI: 10.1101/2024.03.12.584649

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